Kwangmin Choi Selected Research

Neurofibroma

11/2020	Cdkn2a Loss in a Model of Neurofibroma Demonstrates Stepwise Tumor Progression to Atypical Neurofibroma and MPNST.
1/2019	Targeted Inhibition of the Dual Specificity Phosphatases DUSP1 and DUSP6 Suppress MPNST Growth via JNK.
1/2019	STAT3 inhibition reduces macrophage number and tumor growth in neurofibroma.
1/2019	RUNX represses Pmp22 to drive neurofibromagenesis.
1/2017	An inflammatory gene signature distinguishes neurofibroma Schwann cells and macrophages from cells in the normal peripheral nervous system.
7/2016	An ShRNA Screen Identifies MEIS1 as a Driver of Malignant Peripheral Nerve Sheath Tumors.
3/2016	Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation.
6/2013	Canonical Wnt/β-catenin signaling drives human schwann cell transformation, progression, and tumor maintenance.
10/2012	In vivo regulation of TGF-β by R-Ras2 revealed through loss of the RasGAP protein NF1.

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Kwangmin Choi Research Topics

Disease

20	Neoplasms (Cancer) 01/2022 - 07/2009
9	Neurofibrosarcoma (MPNST) 01/2021 - 10/2012
9	Neurofibroma 11/2020 - 10/2012
3	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2022 - 11/2016
3	Sarcoma (Soft Tissue Sarcoma) 01/2021 - 10/2012
3	Plexiform Neurofibroma 01/2021 - 10/2017
3	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/2020 - 01/2017
2	Leukemia 01/2022 - 01/2021
2	Neurofibromatosis 1 (Neurofibromatosis Type I) 01/2021 - 01/2019
2	Inflammation (Inflammations) 01/2020 - 01/2017
2	Neurofibromatoses (Neurofibromatosis) 01/2020 - 07/2013
2	Carcinogenesis 01/2019 - 03/2016
1	Myeloid Leukemia (Leukemia, Myelocytic) 01/2022
1	Fatigue 12/2021
1	Stress Fractures (Stress Fracture) 12/2021
1	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/2021
1	Glioblastoma (Glioblastoma Multiforme) 01/2021
1	Glioma (Gliomas) 01/2020
1	Neurilemmoma (Schwannoma) 01/2020
1	Fibrosis (Cirrhosis) 01/2019
1	Necrosis 01/2019
1	Renal Cell Carcinoma (Grawitz Tumor) 10/2018
1	Melanoma (Melanoma, Malignant) 10/2018
1	Obesity 10/2018
1	Infections 01/2018
1	Bone Marrow Failure Disorders 01/2017
1	Liver Neoplasms (Liver Cancer) 01/2017
1	Osteosarcoma (Osteogenic Sarcoma) 06/2015
1	Breast Neoplasms (Breast Cancer) 12/2014
1	Brain Neoplasms (Brain Tumor) 10/2012
1	Nerve Sheath Neoplasms (Nerve Sheath Neoplasm) 01/2012

Drug/Important Bio-Agent (IBA)

8	Proteins (Proteins, Gene)FDA Link 01/2022 - 07/2009
3	TNF Receptor-Associated Factor 6 (TRAF6)IBA 01/2022 - 01/2017
3	Small Interfering RNA (siRNA)IBA 01/2021 - 07/2016
3	LigandsIBA 01/2021 - 10/2012
3	CytokinesIBA 01/2019 - 01/2017
3	ErbB Receptors (EGF Receptor)IBA 07/2014 - 01/2012
2	Messenger RNA (mRNA)IBA 01/2022 - 10/2018
2	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2021 - 11/2020
2	TensinsIBA 01/2021 - 01/2012
2	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2021 - 01/2012
2	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2020 - 01/2017
2	Histones (Histone)IBA 01/2017 - 03/2016
2	CateninsIBA 03/2016 - 06/2013
1	Deubiquitinating EnzymesIBA 01/2022
1	AlloysIBA 12/2021
1	ElectrolytesIBA 12/2021
1	MagnesiumIBA 12/2021
1	CausticsIBA 12/2021
1	Phosphates (Orthophosphate)IBA 12/2021
1	EnzymesIBA 01/2021
1	Tyrosine Kinase InhibitorsIBA 01/2021
1	Stearoyl-CoA DesaturaseIBA 01/2021
1	Peptide Nucleic AcidsIBA 01/2021
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2021
1	diphosphoric acid (pyrophosphoric acid)IBA 11/2020
1	AZD 6244IBA 11/2020
1	Cyclin-Dependent Kinase Inhibitor p16IBA 11/2020
1	Polo-Like Kinase 1IBA 01/2020
1	Aurora Kinase AIBA 01/2020
1	Protein Kinases (Protein Kinase)IBA 01/2020
1	Aurora KinasesIBA 01/2020
1	Proto-Oncogene Proteins c-sis (Platelet Derived Growth Factor B)IBA 01/2020
1	Tumor Necrosis Factor Receptor-Associated Peptides and ProteinsIBA 01/2020
1	Phosphotransferases (Kinase)IBA 01/2019
1	Core Binding Factors (Core-Binding Factor)IBA 01/2019
1	Protein Isoforms (Isoforms)IBA 01/2019
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 01/2019
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2019
1	2- benzylidene- 3- (cyclohexylamino)- 2,3- dihydro- 1H- inden- 1- oneIBA 01/2019
1	Myelin ProteinsIBA 01/2019
1	Guanosine Triphosphate (GTP)IBA 01/2019
1	Dual-Specificity PhosphatasesIBA 01/2019
1	FLLL 32IBA 01/2019
1	Adenosine Triphosphate (ATP)IBA 10/2018
1	HLA-A Antigens (HLA-A)IBA 10/2017
1	Sp1 Transcription FactorIBA 01/2017
1	Conditioned Culture MediaIBA 01/2017
1	Interferon Type IIBA 01/2017
1	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA 01/2017
1	Polyethylene (Polythene)IBA 01/2017
1	DNA (Deoxyribonucleic Acid)IBA 11/2016
1	Transcription Factors (Transcription Factor)IBA 07/2016
1	RNA (Ribonucleic Acid)IBA 07/2016
1	CD100 antigenIBA 06/2015
1	Antineoplastic Agents (Antineoplastics)IBA 12/2014
1	Betulinic AcidIBA 12/2014
1	Histone MethyltransferasesIBA 12/2014
1	ras ProteinsIBA 10/2012
1	Biological ProductsIBA 07/2009

Therapy/Procedure

5	Therapeutics 11/2020 - 10/2018
3	Transplantation 11/2020 - 03/2016
2	Immunotherapy 10/2018 - 10/2017
1	Drug Therapy (Chemotherapy) 01/2020